For 2006, Bowie once again announced a break from performance, but he made a surprise guest appearance at David Gilmour's 29 May 2006 concert at the Royal Albert Hall in London. He sang "Arnold Layne" and "Comfortably Numb", closing the concert. The former performance was released, on 26 December 2006, as a single.
In May 2007, it was announced that Bowie would curate the High Line Festival in the abandoned railway park in New York called the High Line where he would select various musicians and artists to perform.
Bowie contributed backing vocals to two tracks - "Falling Down" and "Fannin' Street" - on Scarlett Johansson's 2008 album of Tom Waits covers, Anywhere I Lay My Head.
On 29 June 2008, Bowie released a new compilation entitled iSELECT. This CD was a collection of personal favourites compiled by Bowie himself  and was available exclusively as a free gift with the British newspaper The Mail On Sunday. The compilation is notable in that it only contained one major hit single, "Life on Mars?", and concentrated on lesser-known album tracks.
He is confirmed to be playing the 2009
edition of the Coachella
Music & Arts Festival in Indio, CA.